In front of a wall of used 96- and 384-well plates from a 1000-generation long-term evolution experiment; impressive looking, but foul smelling.

 

Our research is aimed at understanding the molecular basis of evolution. The yeast Saccharomyces cerevisiae is an ideal system for studying evolution in the laboratory: yeast is amenable to genetics and genomics studies, and many strains of S. cerevisiae as well as closely related species have been sequenced. These tools allow us to analyze historical events that led to the modern yeast species.

In addition to these case studies in evolution, we are interested in general principles of evolution such as the nature of beneficial and deleterious mutations and how parameters such as mutation rate, the distribution of mutational effects on fitness, and epistasis set the rate of adaptation.

   
  

Department of Biological Sciences | Lehigh University
Iacocca Hall | 111 Research Drive | Bethlehem, PA 18015
Phone: 610.758.6359 | Fax: 610.758.4004



Last Updated: July 2013